Lipo-C

Lipo-C Overview

Lipo-C is a research compound formulated as an L-carnitine derivative with an enhanced lipophilic moiety. It is strictly for laboratory investigation into its potential role in modulating metabolic physiology, specifically focusing on cellular fatty acid transport, mitochondrial beta-oxidation, and systemic metabolic energy regulation.

In controlled laboratory models, Lipo-C is studied for its capability to:

• Increase mitochondrial fatty acid uptake efficiency.
• Support enhanced lipid turnover rates.
• Shift metabolic substrate utilization under experimental conditions of energetic stress.

Lipo-C is employed in scientific settings to investigate the metabolic-endocrine mechanisms controlling lipolysis, fatty acid oxidation, adipocyte metabolism, and the stimulation of mitochondrial biogenesis. Furthermore, investigators examine its potential influence on systemic lipid profiles, fat mass distribution (including visceral fat), and shifts in energy expenditure during experimental dietary or insulin-resistance models.

Lipo-C Structure

Lipo-C is a structurally modified L-carnitine compound, specifically esterified with a lipophilic moiety. This design is intended to improve its bioavailability and targeted delivery to the mitochondria in cellular and animal models. A definitive single molecular formula is not specified due to potential minor structural variations that may exist across different synthetic batches.

The identity and purity for this batch have been confirmed through stringent analytical testing.

Measurement Category

Analytical Data

Observed Mass (MS)

711.9 Da

Purity (HPLC)

99.42%

Batch Reference

2025007

Primary Peak Retention Time

3.48 min

Analytical Instrument

LCMS-7800 Series (Calibrated)

Analytical Note: The primary peak was confirmed by comparing mass and retention time data. A minor secondary peak area was observed at 0.58%.

Lipo-C Research

Lipo-C and its Role in Fatty Acid Metabolism

Experimental research explores Lipo-C’s capacity to enhance the mitochondrial transport of long-chain fatty acids, a prerequisite for their efficient oxidative utilization. These studies suggest that by optimizing fatty acid entry into the mitochondria, Lipo-C may improve cellular energy production and metabolic efficiency under controlled, substrate-rich experimental conditions.

Lipo-C and Cellular Energy Regulation

Further investigations examine Lipo-C’s potential to stimulate lipolytic activity in adipocytes, which promotes free fatty acid turnover and reduces intracellular triglyceride accumulation. Research also explores its potential to induce mitochondrial biogenesis through the activation of critical regulatory pathways, suchel as PGC-1alpha, which is known to govern oxidative enzyme expression and energy metabolism.

Collectively, these findings provide a scientific foundation for studying Lipo-C’s potential applications in metabolic health research—particularly concerning visceral fat reduction, hepatic lipid balance, and insulin sensitivity. Use remains strictly limited to controlled laboratory research by qualified, trained professionals.

The Lipo-C research compound is designated solely for controlled experimental and investigative purposes within certified laboratory environments. It must be handled and utilized only by trained and qualified research professionals. This material is strictly prohibited for human or veterinary use, including any form of therapeutic, diagnostic, or clinical administration.

Article Author: Dr. Charles Hoppel, Ph.D.

Dr. Hoppel is a highly regarded biochemist, widely recognized for his foundational contributions to the study of mitochondrial energy metabolism and the precise biochemical functions of L-carnitine in fatty acid oxidation. Throughout his career, his research has significantly advanced the understanding of mitochondrial transport processes, metabolic regulation, and the mechanisms of carnitine-dependent beta-oxidation under both healthy and diseased conditions.

Scientific Journal Author

Dr. Charles Hoppel has conducted extensive investigations into the metabolism of carnitine and its critical impact on mitochondrial bioenergetics. His work focuses on carnitine’s role in fatty acid transport, oxidative enzyme systems, and energy balance. His research, alongside that of colleagues including W.C. Stanley, C.J. Rebouche, L.L. Jones, and R. Ringseis, has been instrumental in detailing the biochemical and physiological pathways involving L-carnitine and related compounds. This body of work provides the necessary scientific context for modern experimental research into Lipo-C and similar metabolic formulations.

Dr. Hoppel and his collaborators are formally acknowledged for their substantial contributions to advancing the understanding of carnitine metabolism and mitochondrial function. This acknowledgment is solely to credit their scientific research. It does not imply any form of endorsement, sponsorship, or professional affiliation with this product. Montreal Peptides Canada is unaffiliated with Dr. Hoppel or any of the researchers referenced.

Reference Citations

• Stanley WC, et al. Regulation of mitochondrial fatty acid oxidation by L-carnitine. J Mol Cell Cardiol. 1999;31(10):1435-1448. PMID: 10502507.
• Rebouche CJ. Carnitine function and requirements during the life cycle. Fetal Pediatr Pathol. 2004;23(1-2):99-114. PMID: 15362046.
• Jones LL, et al. Role of L-carnitine in cardiovascular disease. Cardiovasc Res. 1999;42(2):219-223. PMID: 10364221.
• Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am J Kidney Dis. 2003;41(4 Suppl 4):S4-12. PMID: 12664513.
• Ringseis R, et al. Carnitine transport and mitochondrial metabolism. Biochim Biophys Acta. 2014;1842(9):1282–1293. PMID: 24950924.
• ClinicalTrials.gov Identifier: NCT01376341. L-carnitine derivative supplementation in metabolic syndrome research.
• ClinicalTrials.gov Identifier: NCT02410932. Mitochondrial fatty acid oxidation enhancement in human research settings.

Storage Instructions

Lipo-C is shipped in a stable, lyophilized (freeze-dried) form, which provides stability for approximately 3–4 months during transit.

Best Practices For Storing Peptides

Adhering to correct storage procedures is essential for maintaining the peptide's integrity, ensuring the accuracy and reliability of laboratory results by preventing contamination, oxidation, and degradation.

Product State

Storage Goal

Optimal Temperature

Key Handling Rule

Lyophilized Powder

Short-Term Preservation

Refrigeration (below 4 degrees Celsius)

Must be kept cool and shielded from light.

Lyophilized Powder

Long-Term Preservation

Freezer (at -80 degrees Celsius)

Avoid frost-free freezers. Minimize freeze-thaw cycles.

Reconstituted Solution

Temporary Use (Up to 30 days)

Refrigeration (below 4 degrees Celsius)

Use sterile buffer (pH 5–6) or bacteriostatic water. Aliquot to prevent repeated thawing.

Preventing Oxidation and Moisture Contamination

• Moisture: Condensation on the cold material must be avoided. When removing peptides from the freezer, always allow the vial to reach room temperature before opening.
• Air Exposure: Minimize exposure to air to prevent oxidation. Store the remaining peptide under a dry, inert gas (nitrogen or argon) when possible. Peptides containing the residues Cysteine (C), Methionine (M), or Tryptophan (W) are particularly sensitive to air.
• Freeze-Thaw Cycles: To maintain long-term stability, avoid frequent thawing and refreezing. A practical approach is to divide the total peptide quantity into smaller aliquots for single-use experiments.

Storing Peptides In Solution

Peptide solutions have a significantly shorter shelf life compared to their lyophilized form and are more susceptible to degradation.

• Susceptible Residues: Peptides containing Cys, Met, Trp, Asp, Gln, or N-terminal Glu residues are known to degrade more rapidly when in solution.
• Recommendations: If solution storage is unavoidable, use sterile buffers with a pH between 5 and 6. Aliquoting is highly recommended to minimize freeze-thaw cycles. Most solutions are stable under refrigeration for up to 30 days.

Peptide Storage Containers

Containers must be clean, durable, and chemically resistant.

• Material: High-quality glass vials offer the best properties, including clarity and chemical inertness. Plastic options (polystyrene or polypropylene) are also suitable.
• Fit: Use containers that are appropriately sized for the peptide quantity to minimize excess air space.

Peptide Storage Guidelines: General Tips

• Store peptides in a cold, dry, and dark environment.
• Avoid repeated freeze-thaw cycles.
• Minimize exposure to air and protect from light.
• Store lyophilized whenever possible for long-term preservation.